铜催化的烯基卤化物的胺化反应：合成烯胺的有效方法。

Copper-catalyzed amination of alkenyl halides: efficient method for the synthesis of enamines.

机构信息

Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.

出版信息

Org Lett. 2010 Jul 2;12(13):2951-3. doi: 10.1021/ol1009416.

DOI:10.1021/ol1009416

PMID:20521777

Abstract

A copper-catalyzed method for the coupling of alkenyl halides with secondary amines has been developed. This protocol used a combination of 10 mol % copper iodide and 20 mol % N,N'-dimethylethane-1,2-diamine as catalyst. The reaction proceeded with various aromatic amines and alkenyl bromides or alkenyl iodides, and the enamines were formed in high yields with excellent regioselectivity and stereoselectivity under the reaction conditions.

摘要

一种铜催化的烯基卤化物与仲胺偶联的方法已经被开发出来。该方案使用 10 mol%碘化亚铜和 20 mol%N,N'-二甲乙二胺的组合作为催化剂。该反应在各种芳香胺和烯基溴化物或烯基碘化物存在下进行，在反应条件下，烯胺以高收率和优异的区域选择性和立体选择性形成。