Department of Pathology, University of South Alabama, Mobile, Alabama, USA.
Breast J. 2010 Jul-Aug;16(4):420-3. doi: 10.1111/j.1524-4741.2010.00925.x. Epub 2010 May 26.
Matrix-producing carcinoma (MPC) of the breast is a rare variant of the uncommon group of malignancies categorized as metaplastic breast carcinomas with heterologous elements. The major criterion for a diagnosis of MPC is the presence of invasive breast carcinoma with the direct transition to a cartilaginous or osseous stromal matrix without an intervening spindle cell component. The cellular origin of MPC remains unclear. It has been suggested that tumor cells in MPC have combined epithelial and mesenchymal features. Several reports have suggested that the tumor cells originate from myoepithelial cells. The prognosis of patients with MPC was originally described as similar to invasive mammary carcinomas of no special type (NST) of the same stage, but a more recent study has shown a worse prognosis than same-stage NSTs.
乳腺基质产生癌（MPC）是一种罕见的变异型，属于少见的化生型乳腺癌，具有异源性成分。MPC 的主要诊断标准是存在浸润性乳腺癌，直接向软骨或骨基质转化，无中间梭形细胞成分。MPC 的细胞起源尚不清楚。有人认为，MPC 中的肿瘤细胞具有上皮和间充质的特征。有几份报告表明，肿瘤细胞起源于肌上皮细胞。最初，MPC 患者的预后与同一分期的无特殊类型（NST）浸润性乳腺癌相似，但最近的一项研究表明，其预后比同分期的 NST 更差。
