Department of Biochemistry and Biomedical Sciences, M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.
Science. 2010 Jul 16;329(5989):294-6. doi: 10.1126/science.1188888. Epub 2010 Jun 3.
Staphylococcus aureus is a major human pathogen that is resistant to numerous antibiotics in clinical use. We found two nonribosomal peptide secondary metabolites--the aureusimines, made by S. aureus--that are not antibiotics, but function as regulators of virulence factor expression and are necessary for productive infections. In vivo mouse models of bacteremia showed that strains of S. aureus unable to produce aureusimines were attenuated and/or cleared from major organs, including the spleen, liver, and heart. Targeting aureusimine synthesis may offer novel leads for anti-infective drugs.
金黄色葡萄球菌是一种主要的人类病原体，对临床使用的许多抗生素具有耐药性。我们发现两种非核糖体肽次级代谢产物——金黄色素，由金黄色葡萄球菌产生——它们不是抗生素，但作为毒力因子表达的调节剂发挥作用，对于生产性感染是必要的。菌血症的体内小鼠模型表明，不能产生金黄色素的金黄色葡萄球菌菌株减弱和/或从主要器官（包括脾、肝和心脏）中清除。靶向金黄色素合成可能为抗感染药物提供新的线索。
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