妥布霉素与大鼠离体膈神经-膈肌标本中的神经肌肉传递
Tobramycin and neuromuscular transmission in the rat isolated phrenic nerve-diaphragm preparation.
作者信息
de Rosayro M, Healy T E
出版信息
Br J Anaesth. 1978 Mar;50(3):251-4. doi: 10.1093/bja/50.3.251.
PMID:205231
Abstract
The effects of different concentrations of tobramycin, streptomycin, neomycin and gentamicin on the rat isolated phrenic nerve-diaphragm preparation are reported. Streptomycin, neomycin and gentamicin produced dose-dependent neuromuscular blockade. Tobramycin increased the muscle response at high concentrations (6.4 X 10(-4) - 2.6 X 10(-2) mol litre-1, but had no detectable effect when used in therapeutically recommended concentrations.
摘要
本文报道了不同浓度的妥布霉素、链霉素、新霉素和庆大霉素对大鼠离体膈神经-膈肌标本的影响。链霉素、新霉素和庆大霉素产生剂量依赖性神经肌肉阻滞。妥布霉素在高浓度（6.4×10⁻⁴ - 2.6×10⁻²摩尔/升）时增加肌肉反应，但在治疗推荐浓度下使用时未检测到明显效果。
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