Pine Meghann, Walter Andrew W
Department of Pediatric Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN 37232-2573, USA.
J Pediatr Hematol Oncol. 2010 Jul;32(5):e192-4. doi: 10.1097/MPH.0b013e3181e03082.
Pancytopenia in hospitalized children is not a common occurrence. The causes may vary in different patients and in diverse areas of the world. There are no reports in the literature describing these etiologies in a developed country. Our review focused on children presenting with pancytopenia at a children's hospital in the United States with the purpose to allow us to better evaluate and care for children.
Charts of children aged 2 months to 18 years who were admitted to our hospital over a 5-year period were retrospectively reviewed to identify the diagnosis of pancytopenia. The diagnosis of pancytopenia was confirmed by laboratory values showing neutropenia, anemia, and thrombocytopenia. These etiologies and patient characteristics were reported in our review.
A total of 64 children were identified with the diagnosis of pancytopenia. The most common diagnoses were infectious in origin (64%), followed by hematologic (28%), and miscellaneous (8%) etiologies.
The most common etiology of pancytopenia in hospitalized children without cancer was infections. This differs from earlier reports in other countries, where megaloblastic anemia was found most often. Our review should provide guidance to the diagnoses which should be considered when evaluating a child with pancytopenia.
住院儿童全血细胞减少并不常见。病因在不同患者和世界不同地区可能有所不同。文献中尚无关于发达国家这些病因的报道。我们的综述聚焦于美国一家儿童医院出现全血细胞减少的儿童，目的是使我们能更好地评估和照料儿童。
回顾性分析我院5年内收治的2个月至18岁儿童的病历，以确定全血细胞减少的诊断。全血细胞减少的诊断通过实验室检查结果显示中性粒细胞减少、贫血和血小板减少来确认。我们的综述报告了这些病因及患者特征。
共确定64例全血细胞减少诊断病例。最常见的诊断病因是感染性（64%），其次是血液学病因（28%）和其他病因（8%）。
非癌症住院儿童全血细胞减少最常见的病因是感染。这与其他国家早期报道不同，其他国家最常发现的是巨幼细胞贫血。我们的综述应为评估全血细胞减少儿童时应考虑的诊断提供指导。
