在绵羊模型中，与标准聚四氟乙烯（PTFE）移植物相比，具有腔内固定肝素的PTFE移植物在六个月时通畅性得到改善，内膜增生减少。
Improved patency and reduced intimal hyperplasia in PTFE grafts with luminal immobilized heparin compared with standard PTFE grafts at six months in a sheep model.
作者信息
Pedersen G, Laxdal E, Ellensen V, Jonung T, Mattsson E
机构信息
Surgical Clinic, Haukeland University Hospital, Bergen, Norway.
出版信息
J Cardiovasc Surg (Torino). 2010 Jun;51(3):443-8.
AIM
The aim of this study was to compare the performance of polytetrafluoroethylene (PTFE) grafts with luminal coating of immobilized heparin to that of standard PTFE grafts at six months.
METHODS
Twenty-eight common carotid arteries in fourteen sheep were bypassed with heparin-coated PTFE grafts (6 mm diameter, 6 cm length) on one side and standard PTFE grafts on the other. The grafts were explanted after six months. The thickness of intimal hyperplasia (IH) in open grafts was measured with histomorphometrical methods.
RESULTS
Two of 14 heparinized PTFE grafts and nine of 14 grafts in the control PTFE-group were occluded at explantation (P=0.006). Six-month patency rates for heparinized PTFE grafts and for standard PTFE grafts were 86% and 36%, respectively. Mean graft anastomotic IH thickness in open grafts were 0.074 mm for heparinized PTFE grafts and 0.259 mm for PTFE-grafts (P=0.006).
CONCLUSION
PTFE grafts with luminal coating containing immobilized heparin had significantly better patency and recruited less intimal hyperplasia than standard PTFE grafts at six months.
目的
本研究旨在比较固定化肝素腔内涂层聚四氟乙烯（PTFE）移植物与标准PTFE移植物在六个月时的性能。
方法
用肝素涂层PTFE移植物（直径6mm，长度6cm）旁路移植14只绵羊的28条颈总动脉，一侧用肝素涂层PTFE移植物，另一侧用标准PTFE移植物。六个月后取出移植物。用组织形态计量学方法测量开放移植物内膜增生（IH）的厚度。
结果
在取出时，14个肝素化PTFE移植物中有2个闭塞，14个对照PTFE组移植物中有9个闭塞（P=0.006）。肝素化PTFE移植物和标准PTFE移植物的六个月通畅率分别为86%和36%。开放移植物中，肝素化PTFE移植物的平均移植物吻合口IH厚度为0.074mm，PTFE移植物为0.259mm（P=0.006）。
结论
六个月时，含有固定化肝素的腔内涂层PTFE移植物的通畅性明显优于标准PTFE移植物，内膜增生也较少。
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