Jeong Taek Jo, Lee Eun Ju, Haw Sik, Shin Min Kyung, Haw Choong Rim
Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.
Ann Dermatol. 2009 Nov;21(4):409-12. doi: 10.5021/ad.2009.21.4.409. Epub 2009 Nov 30.
An amelanotic malignant melanoma is characterized by little or no pigment. It is frequently misdiagnosed because it is a rare entity in general, and because of its unusual clinical features. Liposarcoma is one of the most common adult soft tissue sarcomas. We encountered a case of amelanotic melanoma with a concurrent liposarcoma. A 68-year-old man presented with a single, 1.5x1.5 cm round erythematous, eroded nodule on the left heel. A biopsy specimen showed atypical, pleomorphic tumor cells with little melanin pigment. The tumor cells were positive for S-100, HMB-45 and negative for cytokeratins. These findings were consistent with amelanotic melanoma. On positron emission tomography/computed tomography (PET/CT), a hypermetabolic lesion was found in the left buttock. This lesion was excised and diagnosed as a well-differentiated liposarcoma. An association between sarcomas and other primary malignancies has been reported. However, an association between melanoma and liposarcoma is rare.
无色素性恶性黑色素瘤的特征是色素很少或没有色素。它经常被误诊，这是因为总体上它是一种罕见的疾病，还因为其不寻常的临床特征。脂肪肉瘤是最常见的成人软组织肉瘤之一。我们遇到了一例同时患有无色素性黑色素瘤和脂肪肉瘤的病例。一名68岁男性患者，左足跟出现一个1.5×1.5厘米的单发圆形红斑、糜烂性结节。活检标本显示非典型、多形性肿瘤细胞，黑色素很少。肿瘤细胞S-100、HMB-45呈阳性，细胞角蛋白呈阴性。这些发现符合无色素性黑色素瘤。在正电子发射断层扫描/计算机断层扫描（PET/CT）上，左侧臀部发现一个高代谢病变。切除该病变后诊断为高分化脂肪肉瘤。肉瘤与其他原发性恶性肿瘤之间的关联已有报道。然而，黑色素瘤与脂肪肉瘤之间的关联很少见。
