Ekblom Anders, Hansson Per, Thomsson Mats
Department of Physiology II, Karolinska Institutet, Box 60400, S-104 01 StockholmSweden Department of Neurology, Karolinska Sjukhuset, Box 60500, S-104 01 StockholmSweden Department of Oral Surgery, Södersjukhuset, Box 38100, S-100 64 StockholmSweden.
Pain. 1991 Mar;44(3):249-254. doi: 10.1016/0304-3959(91)90093-D.
Aiming at optimizing serotonin levels in endogenous pain-modulating systems, L-tryptophan supplementation pre- and postoperatively (2 g/day for 7 days) did not affect pain development or analgesic consumption after third molar surgery. Biological effects related to an increase in mood were observed, however, indicating transport of L-tryptophan to the central nervous system. The findings are discussed in relation to earlier reports on favorable effects of L-tryptophan on experimental pain in healthy subjects and in chronic pain patients.
为了优化内源性疼痛调节系统中的血清素水平，在第三磨牙手术后，术前和术后补充L-色氨酸（每天2克，持续7天）对疼痛发展或镇痛药物的使用没有影响。然而，观察到了与情绪改善相关的生物学效应，这表明L-色氨酸被转运到了中枢神经系统。结合之前关于L-色氨酸对健康受试者和慢性疼痛患者实验性疼痛有积极作用的报道，对这些研究结果进行了讨论。
