原发性食管CD30阳性ALK阳性间变性大细胞淋巴瘤：1例报告并文献复习
Primary esophageal CD30-positive ALK-positive anaplastic large cell lymphoma: a case report and literature review.
作者信息
Wu Ning, Pang Liewen, Chen Zhiming, Wang Yiqing, Ma Qinyun, Chen Gang, Chen Ji, Huang Jiechun
机构信息
Department of Cardiothoracic Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China.
出版信息
J Gastrointest Cancer. 2011 Mar;42(1):57-60. doi: 10.1007/s12029-010-9147-y.
PURPOSE
To introduce a case of primary esophageal CD30-positive ALK-positive anaplastic large cell lymphoma (ALCL) and discuss its diagnosis and treatment.
METHODS
Esophagectomy was done for a 37-year-old male with a submucosal lesion after a frozen section failed to give a definite diagnosis. Samples were sent for hematoxylin-eosin staining and immunohistochemical analysis. Six cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy were given and the patient was followed up.
RESULTS
The operation was uneventful. Postoperative pathologic and immunohistochemical examination yielded a diagnosis of primary CD30-positive and ALK-positive ALCL of the esophagus. The patient was in complete remission at the 14-month follow-up.
CONCLUSIONS
ALCL of the esophagus should be considered in the differential diagnosis of esophageal submucosal lesions. Biopsy through either esophagoscopy or surgical exploration, chemotherapy, and radiotherapy can be chosen for long-term survival.
目的
介绍一例原发性食管CD30阳性、ALK阳性间变性大细胞淋巴瘤（ALCL）病例，并讨论其诊断和治疗。
方法
对一名37岁男性患者进行了食管切除术，该患者有黏膜下病变，冰冻切片未能明确诊断。样本送去进行苏木精-伊红染色和免疫组织化学分析。给予六个周期的CHOP（环磷酰胺、阿霉素、长春新碱和泼尼松）化疗，并对患者进行随访。
结果
手术顺利。术后病理和免疫组织化学检查确诊为原发性食管CD30阳性和ALK阳性ALCL。在14个月的随访中，患者完全缓解。
结论
食管ALCL应在食管黏膜下病变的鉴别诊断中予以考虑。可选择通过食管镜活检或手术探查、化疗和放疗以实现长期生存。
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