Eremenko A A, Kolpakov P E, Babaev M A, Revunenkov G V, Fominykh M V
Anesteziol Reanimatol. 2010 Mar-Apr(2):24-6.
The impact of administration of the calcium sensitizer levosimendan on hemodynamic parameters, dose of intraoperative and postoperative cardiotonic maintenance, length of intensive care unit stay, and hospital mortality was studied in cardiosurgical patients with dilated cardiomyopathy, second-fourth degree mitral valve insufficiency, or NYHA Class IV circulatory insufficiency. Levosimendan was administered to 25 patients 3-5 days prior to surgery. A control group of 22 patients did not receive levosimendan. The use of the agent caused statistically significant reductions in pulmonary artery pressure and pulmonary wedge pressure and increases in cardiac index and left ventricular ejection fraction. The levosimedan-treated patients needed smaller doses of sjmpathomimetics, less length of intensive care unit stay and showed lower mortality rates (p < O.05 for all indices).
在患有扩张型心肌病、二至四度二尖瓣关闭不全或纽约心脏协会（NYHA）IV级循环功能不全的心脏外科手术患者中，研究了钙增敏剂左西孟旦的给药对血流动力学参数、术中和术后强心维持剂量、重症监护病房停留时间及医院死亡率的影响。在手术前3 - 5天，对25例患者给予左西孟旦。22例患者的对照组未接受左西孟旦。使用该药物导致肺动脉压和肺楔压在统计学上显著降低，心脏指数和左心室射血分数增加。接受左西孟旦治疗的患者需要较小剂量的拟交感神经药，重症监护病房停留时间更短，且死亡率更低（所有指标p < 0.05）。
