Toxicology Investigator Network Authorship Group Wilford Hall Medical Center, USA.
Clin Toxicol (Phila). 2010 Jun;48(5):424-30. doi: 10.3109/15563650.2010.486381.
Oral and intravenous (IV) N-acetylcysteine (NAC) are used for the treatment of acetaminophen poisoning. The objective of this multicenter study was to compare the safety of these two routes of administration.
We conducted a multicenter chart review of all patients treated with NAC for acetaminophen poisoning. The primary safety outcome was the percentage of patients with NAC-related adverse events.
A total of 503 subjects were included in the safety analysis (306 IV-only, 145 oral-only, and 52 both routes). There were no serious adverse events related to NAC for either route. Nausea and vomiting were the most common related adverse events and were more common with oral treatment (23 vs. 9%). Anaphylactoid reactions were more common with IV administration (6 vs. 2%).
IV and oral NAC are generally mild adverse drug reactions.
口服和静脉（IV）乙酰半胱氨酸（NAC）用于治疗对乙酰氨基酚中毒。本多中心研究的目的是比较这两种给药途径的安全性。
我们对所有接受 NAC 治疗对乙酰氨基酚中毒的患者进行了多中心图表回顾。主要安全性结果是与 NAC 相关的不良事件的百分比。
共有 503 名受试者纳入安全性分析（306 例仅 IV，145 例仅口服，52 例两种途径）。两种途径均未发生与 NAC 相关的严重不良事件。恶心和呕吐是最常见的相关不良事件，且口服治疗更为常见（23%比 9%）。过敏样反应更常见于 IV 给药（6%比 2%）。
IV 和口服 NAC 通常是轻微的药物不良反应。
