从感染恒河猴中分离、鉴定肺炎链球菌及对照疗效
Isolation, identification of Streptococcus pneumoniae from infected rhesus monkeys and control efficacy.
作者信息
Zou Shasha, Luo Qihui, Chen Zhengli, Cheng Anchun, Wang Mingshu, Zhu Dekang, Jia Renyong, Liu Fei, Chen Xiaoyue, Zhou Yi, Bi Fengjun, Yang Zexia
机构信息
Key Laboratory of Animal Diseases and Human Health of Sichuan Province, Ya'an, Sichuan, China.
出版信息
J Med Primatol. 2010 Dec;39(6):417-23. doi: 10.1111/j.1600-0684.2010.00427.x.
BACKGROUND
Streptococcus pneumoniae can cause a wide variety of illnesses. Primate animals can be infected by the pneumococcus. A disease occurred among rhesus monkeys in winter 2006.
METHODS
Routine clinical observation, necropsies, bacteriological examinations were conducted, and PCR, pathogenicity to BALB/c mice and antibiotic susceptibility test were examined additionally.
RESULTS
We conclude that the agent is S. pneumoniae. Based on the antibiotic susceptibility test, a dose of 20 mg/kg body weight daily of Erythromycin was given intramuscular injection for 5 days, resulting in the disappearance of clinical signs, and no newly case reappear be observed till today.
CONCLUSIONS
Therefore, it is suggested that the outbreak of respiratory disease in the rhesus monkeys was because of transmission of S. pneumoniae among rhesus monkeys. The antibiotic therapy finding underscores the utility of Erythromycin to cure the infected rhesus monkeys without causing side effects and without contributing to the further development of antibiotic resistance.
背景
肺炎链球菌可引发多种疾病。灵长类动物可被肺炎球菌感染。2006年冬季恒河猴中发生了一种疾病。
方法
进行常规临床观察、尸检、细菌学检查，并额外进行聚合酶链反应、对BALB/c小鼠的致病性及抗生素敏感性试验。
结果
我们得出病原体为肺炎链球菌的结论。根据抗生素敏感性试验，每日按20毫克/千克体重的剂量肌内注射红霉素，持续5天，临床症状消失，直至今日未观察到新病例再次出现。
结论
因此，提示恒河猴呼吸道疾病的暴发是由于肺炎链球菌在恒河猴之间传播所致。抗生素治疗结果强调了红霉素在治愈感染恒河猴方面的效用，且不会引起副作用，也不会导致抗生素耐药性的进一步发展。
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