Hawley H B, Yamada T, Mosher D F, Fine D P, Berendt R F
J Med Primatol. 1977;6(4):203-18. doi: 10.1159/000459748.
Disseminated intravascular coagulation (DIC) was induced in both normal and asplenic rhesus monkeys by intravenous challenge with Streptococcus pneumoniae. Our observations in the infected monkeys have led us to conclude that (1) pneumococcal capsular polysaccharide (PCP), immune complexes and complement may not have primary roles in the initiation of DIC; (2) intact pneumococci may be catalysts for the development of DIC; (3) the initial event in DIC may be activation of Hageman factor; and (4) evidence of activation of Hageman factor-dependent systems is present regardless of severity of infection.
通过静脉注射肺炎链球菌对正常和无脾恒河猴诱导弥散性血管内凝血（DIC）。我们对受感染猴子的观察结果使我们得出以下结论：（1）肺炎球菌荚膜多糖（PCP）、免疫复合物和补体可能在DIC的启动中不发挥主要作用；（2）完整的肺炎球菌可能是DIC发展的催化剂；（3）DIC的初始事件可能是Hageman因子的激活；（4）无论感染的严重程度如何，均存在Hageman因子依赖性系统激活的证据。
