Small Animal Medical Clinic, Ludwig Maximilian University, Veterinärstrasse 13, 80539 Munich, Germany.
Vet Rec. 2010 Jun 5;166(23):710-4. doi: 10.1136/vr.4850.
The success rates and adverse effects of a selamectin spot-on preparation, given orally weekly or every other week, against canine generalised demodicosis were evaluated in 44 dogs, 39 with juvenile-onset demodicosis and five with adult-onset demodicosis. The dogs received selamectin at a dose of 24 to 48 mg/kg once a week, or the same dose every two weeks. Thirty-eight dogs completed the study, four dogs were lost to follow-up and two dogs died. Nine dogs went into remission: all had the juvenile-onset form of the disease. There was no difference between the two treatment groups, but dogs with clinical scores of 65 or less responded significantly better than those with a score of over 65 (P=0.0015). The most frequent adverse effects were vomiting and diarrhoea. Two dogs exhibited mild reversible neurological side effects, which resolved with cessation of treatment. Difficulties in oral administration were observed in several dogs.
评估了每周或每两周口服一剂塞拉菌素点眼剂治疗犬全身性蠕形螨病的成功率和不良反应。44 只犬接受了 24 至 48 毫克/千克的塞拉菌素剂量，每周一次或每两周一次。38 只狗完成了研究，4 只狗失访，2 只狗死亡。9 只狗缓解：均为幼年发病形式。两组治疗无差异，但临床评分 65 分或以下的狗比评分超过 65 分的狗反应明显更好（P=0.0015）。最常见的不良反应是呕吐和腹泻。两只狗出现轻度可逆的神经副作用，停药后消失。几只狗在口服给药时遇到困难。
