Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Cancer J. 2010 May-Jun;16(3):235-40. doi: 10.1097/PPO.0b013e3181e075e9.
Although liver metastases from colorectal cancer previously conferred a very dismal prognosis, advances in systemic therapy combined with surgical techniques now gives these patients a reasonable chance for cure. Traditional cytoxic chemotherapy combined with biologic agents result in impressive response rates, allowing a portion of patients who were considered unresectable to undergo hepatectomy with curative intent. This review discusses the role of systemic therapy in patients with liver-limited metastatic disease for patients with resectable, potentially resectable and unresectable disease.
虽然结直肠癌肝转移以前预后非常差，但系统治疗的进步加上手术技术现在为这些患者提供了合理的治愈机会。传统细胞毒性化疗联合生物制剂可产生令人印象深刻的反应率，使一部分被认为不可切除的患者有机会进行以治愈为目的的肝切除术。这篇综述讨论了系统治疗在可切除、潜在可切除和不可切除疾病患者肝转移疾病中的作用。
