Werner R S, McCormick B, Petrek J, Cox L, Cirrincione C, Gray J R, Yahalom J
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Radiology. 1991 Jul;180(1):177-84. doi: 10.1148/radiology.180.1.2052688.
To identify risk factors in the development of arm edema (AE) after conservative management of breast cancer, the authors prospectively measured differences in upper and lower arm circumference in 282 patients with stage I or II breast cancer who received radiation. AE was defined as a difference of 2.5 cm or more in either measurement between treated and untreated arms. Median follow-up was 37 months (range, 7-109 months). The crude frequency of AE overall was 19.5% (55 patients). In 21 patients (7.4%) AE was transient; 34 patients (12.1%) had persistent AE, which is the focus of this article. The 5-year actuarial incidence of persistent AE was 16%. The crude risk of persistent severe AE was 3.9%. Various factors were examined for their ability to enable prediction of AE. Treatment-related factors did not significantly enable prediction of AE, whereas factors related to patient size, such as body mass index, were strongly associated with both the frequency and severity of AE.
为了确定乳腺癌保守治疗后发生手臂水肿（AE）的风险因素，作者前瞻性地测量了282例接受放疗的I期或II期乳腺癌患者上臂和下臂周长的差异。AE定义为治疗侧与未治疗侧手臂的任何一项测量差值达2.5厘米或以上。中位随访时间为37个月（范围7 - 109个月）。AE的总体粗发生率为19.5%（55例患者）。21例患者（7.4%）的AE为短暂性；34例患者（12.1%）有持续性AE，这是本文的重点。持续性AE的5年精算发病率为16%。持续性严重AE的粗风险为3.9%。研究了各种因素预测AE的能力。与治疗相关的因素不能显著预测AE，而与患者体型相关的因素，如体重指数，与AE的发生率和严重程度均密切相关。
