β-连环蛋白、葡萄糖转运蛋白1（Glut-1）和第10号染色体缺失的磷酸酶和张力蛋白同源物（PTEN）在增殖期子宫内膜、子宫内膜上皮内瘤变及子宫内膜样腺癌中的表达及意义
Expression and significance of beta-catenin, Glut-1 and PTEN in proliferative endometrium, endometrial intraepithelial neoplasia and endometrioid adenocarcinoma.
作者信息
Xiong Y, Xiong Y Y, Zhou Y F
机构信息
Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China.
出版信息
Eur J Gynaecol Oncol. 2010;31(2):160-4.
OBJECTIVE
The aim of this study was to explore the potentiality of beta-catenin, Glut-1 and PTEN proteins as markers for a diagnosis of endometrial intraepithelial neoplasia (EIN).
DESIGN
Ten proliferative endometrium, 83 endometrial hyperplasia (59 benign hyperplasia, 24 EIN) and 24 endometrioid adenocarcinoma sections were immunostained for beta-catenin, Glut-1 and PTEN protein expression.
RESULTS
(1) Abnormal expression of beta-catenin was detected in 10% of benign hyperplasia, 50% of EIN and 67% of endometriold adenocarcinoma. (2) Overexpression of Glut-1 was present in 58% of EIN and 71% of endometrioid adenocarcinoma. (3) Complete loss of PTEN immunoreactivity was found in 20% of proliferative endometrium, 29% of benign hyperplasia, 38% of EIN and 63% of endometrioid adenocarcinoma.
CONCLUSIONS
The abnormal expression of beta-catenin and overexpression of Glut-1 may be useful markers in distinguishing benign hyperplasia from EIN, whereas lack of PTEN expression is not an appropriate marker for a diagnosis of EIN.
目的
本研究旨在探讨β-连环蛋白、葡萄糖转运蛋白1（Glut-1）和第10号染色体缺失的磷酸酶和张力蛋白同源物（PTEN）蛋白作为诊断子宫内膜上皮内瘤变（EIN）标志物的潜力。
设计
对10例增殖期子宫内膜、83例子宫内膜增生（59例良性增生、24例EIN）和24例子宫内膜样腺癌切片进行β-连环蛋白、Glut-1和PTEN蛋白表达的免疫染色。
结果
（1）在10%的良性增生、50%的EIN和67%的子宫内膜样腺癌中检测到β-连环蛋白异常表达。（2）58%的EIN和71%的子宫内膜样腺癌中存在Glut-1过表达。（3）在20%的增殖期子宫内膜、29%的良性增生、38%的EIN和63%的子宫内膜样腺癌中发现PTEN免疫反应性完全丧失。
结论
β-连环蛋白的异常表达和Glut-1的过表达可能是区分良性增生与EIN的有用标志物，而PTEN表达缺失不是诊断EIN的合适标志物。
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