Zhou Wei-Xun, Liang Zhi-Yong, Gao Jie, Liu Tong-Hua
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Zhonghua Bing Li Xue Za Zhi. 2009 Jun;38(6):393-6.
To investigate the diagnostic applications of endometrial intraepithelial neoplasia (EIN), and the expression of PTEN in endometrial lesions.
Fifty-one cases of endometrial lesions were enrolled in this study. Using diagnostic criteria of EIN, the diagnosis were made and compared with the original results. Immunohistochemistry for PTEN was performed in all cases.
Two cases of simple hyperplasia originally diagnosed were reclassified as EIN. Three cases with atypia originally diagnosed showed no EIN pattern. PTEN deletion rates were 50.0%, 50.0%, 66.7% and 81.8% in proliferative endometrium, benign hyperplasia, EIN and endometrial carcinoma, respectively.
Diagnosis of EIN is applicable and its morphology and diagnostic criteria are different from the classical one (WHO94) for endometrial hyperplasia. Detection of PTEN deletion by immunohistochemistry is useful in identifying EIN, but cannot be used as an ultimate confirming factor.
探讨子宫内膜上皮内瘤变（EIN）的诊断应用以及PTEN在子宫内膜病变中的表达。
本研究纳入51例子宫内膜病变病例。采用EIN诊断标准进行诊断，并与原诊断结果进行比较。对所有病例进行PTEN免疫组织化学检测。
2例原诊断为单纯性增生的病例重新分类为EIN。3例原诊断为非典型增生的病例未显示EIN模式。增殖期子宫内膜、良性增生、EIN和子宫内膜癌中PTEN缺失率分别为50.0%、50.0%、66.7%和81.8%。
EIN诊断具有实用性，其形态学和诊断标准不同于经典的子宫内膜增生诊断标准（WHO94）。通过免疫组织化学检测PTEN缺失有助于识别EIN，但不能作为最终确诊因素。
