Wierzba Tomasz H
Katedra i Zakład Fizjologii, Akademia Medyczna, Gdańsk.
Kardiol Pol. 2005 Oct;63(4 Suppl 2):S472-82.
Data from a variety of experimental studies suggesting benefits of the antioxidant supplementation were confronted with those from clinical trials and large metaanalyses which have failed to prove those benefits. Major directions of the biological effects of reactive oxygen species (ROS) and antioxidants were specified. In particular, plausible mechanisms through antioxidants may disturb physiological functions were discussed. The regulatory aspects of ROS potency, and the ways antioxidants may disturb homeostasis were taken particularly into account. Directions of prospective research towards practical use of antioxidants were suggested.
来自各种实验研究表明抗氧化剂补充剂有益的数据，与来自临床试验和大型荟萃分析的数据相矛盾，后者未能证明这些益处。明确了活性氧（ROS）和抗氧化剂生物学效应的主要方向。特别讨论了抗氧化剂可能干扰生理功能的合理机制。特别考虑了ROS效力的调节方面以及抗氧化剂可能干扰体内平衡的方式。提出了抗氧化剂实际应用的前瞻性研究方向。
