蟾蜍膀胱中环磷酸腺苷的动力学

Kinetics of cyclic AMP in toad bladder.

作者信息

Ekblad E B, Licko V

出版信息

Biochim Biophys Acta. 1978 Apr 19;540(1):173-82. doi: 10.1016/0304-4165(78)90446-4.

PMID:205277

Abstract

Tissue distributions of cyclic [3H]AMP and [14C]inulin in toad bladder were determined and their kinetics analyzed. We found that both the epithelial and the other cells of the toad bladder handle cyclic AMP similarly. Moreover, we found that the distribution of cyclic AMP did not differ from that of inulin, an extracellular marker. Kinetic analysis suggests that the rate coefficient of cyclic AMP metabolism is much larger than the exchange rate coefficient, which explains why distribution of both cyclic AMP and inulin are similar.

摘要

测定了蟾蜍膀胱中环状[³H]AMP和[¹⁴C]菊粉的组织分布，并分析了它们的动力学。我们发现蟾蜍膀胱的上皮细胞和其他细胞处理环状AMP的方式相似。此外，我们发现环状AMP的分布与细胞外标志物菊粉的分布没有差异。动力学分析表明，环状AMP代谢的速率系数远大于交换速率系数，这解释了为什么环状AMP和菊粉的分布相似。