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本文引用的文献

1
The similarity of effects of vasopressin, adenosine-3',5'-phosphate (cyclic AMP) and theophylline on the toad bladder.血管加压素、腺苷 - 3',5'-磷酸（环磷酸腺苷）和茶碱对蟾蜍膀胱作用的相似性。
J Clin Invest. 1962 Apr;41(4):702-9. doi: 10.1172/JCI104528.
2
THE ACTION OF EPINEPHRINE AND THE ROLE OF THE ADENYL CYCLASE SYSTEM IN HORMONE ACTION.肾上腺素的作用及腺苷酸环化酶系统在激素作用中的角色。
Recent Prog Horm Res. 1965;21:623-46.
3
The effects of neurohypophysial extracts on the water transfer across the wall of the isolated urinary bladder of the toad Bufo marinus.神经垂体提取物对海蟾蜍离体膀胱壁水转运的影响。
J Endocrinol. 1958 Sep;17(3):201-9. doi: 10.1677/joe.0.0170201.
4
Active sodium transport by the isolated toad bladder.离体蟾蜍膀胱的主动钠转运
J Gen Physiol. 1958 Mar 20;41(4):657-68. doi: 10.1085/jgp.41.4.657.
5
Adenosine 3',5'-monophosphate as the intracellular mediator of the action of adrenocorticotropic hormone on the adrenal cortex.3',5'-环磷酸腺苷作为促肾上腺皮质激素作用于肾上腺皮质的细胞内介质。
J Biol Chem. 1967 Dec 10;242(23):5535-41.
6
The effect of vasopressin and of theophylline on the concentration of adenosine 3',5'-phosphate in the urinary bladder of the toad.血管加压素和茶碱对蟾蜍膀胱中3',5'-磷酸腺苷浓度的影响。
J Biol Chem. 1965 Nov;240(11):4524-6.
7
Amiloride: a potent inhibitor of sodium transport across the toad bladder.氨氯地平：蟾蜍膀胱钠转运的强效抑制剂。
J Physiol. 1968 Mar;195(2):317-30. doi: 10.1113/jphysiol.1968.sp008460.
8
Threshold and receptor reserve in the action of neurohypophyseal peptides. A study of synergists and antagonists of the hydroosmotic response of the toad urinary bladder.神经垂体肽作用中的阈值与受体储备。蟾蜍膀胱水渗透性反应的协同剂和拮抗剂研究。
J Gen Physiol. 1970 Aug;56(2):250-71. doi: 10.1085/jgp.56.2.250.
9
Neurohypophyseal hormone-sensitive adenyl cyclase of toad urinary bladder.蟾蜍膀胱神经垂体激素敏感腺苷酸环化酶
Proc Natl Acad Sci U S A. 1970 Sep;67(1):7-12. doi: 10.1073/pnas.67.1.7.
10
Effect of renal medullary solutes on vasopressin-sensitive adenyl cyclase.肾髓质溶质对血管升压素敏感腺苷酸环化酶的作用。
Am J Physiol. 1972 Mar;222(3):657-62. doi: 10.1152/ajplegacy.1972.222.3.657.

环磷酸腺苷与钠转运。蟾蜍膀胱中的定量及时间关系

Cyclic AMP and sodium transport. Quantitative and temporal relationships in toad urinary bladder.

作者信息

Sapirstein V S, Scott W N

出版信息

J Clin Invest. 1973 Sep;52(9):2379-82. doi: 10.1172/JCI107426.

DOI:10.1172/JCI107426
PMID:4353777
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC333042/
Abstract

The effects of oxytocin upon tissue cAMP content and short-circuit current (SCC) were measured in the urinary bladder of the toad, Bufo marinus. Tissue cAMP levels doubled before any increment in SCC was observed, the two hormone responses were quantitatively related, and a threshold level for an effect of cAMP upon sodium transport was demonstrated. The period of time over which cAMP levels continued to rise after the threshold level had been attained seemed invariant with hormone concentration. The rate at which cAMP levels rose increased with hormone concentration yielding hormone concentration-dependent maximal levels. The decay of cAMP levels was delayed when sodium influx was curtailed, suggesting a sodium-regulatory effect upon tissue cAMP levels.

摘要

在海蟾蜍（Bufo marinus）的膀胱中测量了催产素对组织环磷酸腺苷（cAMP）含量和短路电流（SCC）的影响。在观察到SCC增加之前，组织cAMP水平增加了一倍，这两种激素反应在数量上相关，并且证明了cAMP对钠转运作用的阈值水平。在达到阈值水平后，cAMP水平持续升高的时间段似乎与激素浓度无关。cAMP水平升高的速率随激素浓度增加，产生激素浓度依赖性的最大水平。当钠流入减少时，cAMP水平的衰减延迟，表明对组织cAMP水平有钠调节作用。