环磷酸腺苷与钠转运。蟾蜍膀胱中的定量及时间关系
Cyclic AMP and sodium transport. Quantitative and temporal relationships in toad urinary bladder.
作者信息
Sapirstein V S, Scott W N
出版信息
J Clin Invest. 1973 Sep;52(9):2379-82. doi: 10.1172/JCI107426.
Abstract
The effects of oxytocin upon tissue cAMP content and short-circuit current (SCC) were measured in the urinary bladder of the toad, Bufo marinus. Tissue cAMP levels doubled before any increment in SCC was observed, the two hormone responses were quantitatively related, and a threshold level for an effect of cAMP upon sodium transport was demonstrated. The period of time over which cAMP levels continued to rise after the threshold level had been attained seemed invariant with hormone concentration. The rate at which cAMP levels rose increased with hormone concentration yielding hormone concentration-dependent maximal levels. The decay of cAMP levels was delayed when sodium influx was curtailed, suggesting a sodium-regulatory effect upon tissue cAMP levels.
摘要
在海蟾蜍（Bufo marinus）的膀胱中测量了催产素对组织环磷酸腺苷（cAMP）含量和短路电流（SCC）的影响。在观察到SCC增加之前，组织cAMP水平增加了一倍，这两种激素反应在数量上相关，并且证明了cAMP对钠转运作用的阈值水平。在达到阈值水平后，cAMP水平持续升高的时间段似乎与激素浓度无关。cAMP水平升高的速率随激素浓度增加，产生激素浓度依赖性的最大水平。当钠流入减少时，cAMP水平的衰减延迟，表明对组织cAMP水平有钠调节作用。
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