Department of Endocrinology, 424 Military Hospital, Thessaloniki, Greece.
Gynecol Endocrinol. 2011 Jun;27(6):384-90. doi: 10.3109/09513590.2010.493963. Epub 2010 Jun 9.
Thyroid dysfunction during pregnancy may result in both maternal and neonatal complications. Subacute thyroiditis (SAT) is an extremely rare cause of both hyper- and hypothyroidism in pregnant women.
A case of first trimester SAT is presented. Diagnosis of SAT was based on fine-needle aspiration biopsy. The disease resolved spontaneously without need for prednisone administration but a hypothyroid phase treated with T4 throughout pregnancy occurred. The pregnancy resulted in a healthy full term infant. We measured various cytokine levels in an attempt to follow their course during SAT as well as throughout the remaining period of pregnancy. Serum thyreoglobulin (Tg) levels correlated best with thyroid function tests (TFTs) and the course of SAT.
The diagnosis of SAT at a pregnancy setting may be intriguing. The measurement of circulating cytokines is not helpful in the differential diagnosis or monitoring of the disease.
妊娠期间甲状腺功能障碍可能导致母体和新生儿并发症。亚急性甲状腺炎（SAT）是孕妇发生甲亢和甲减的极罕见病因。
现介绍一例妊娠早期 SAT 病例。SAT 的诊断基于细针穿刺活检。疾病未经泼尼松治疗而自发缓解，但整个妊娠期间出现了甲状腺功能减退期，需要用 T4 治疗。妊娠结局为健康足月婴儿。我们测量了各种细胞因子水平，试图了解它们在 SAT 期间以及整个妊娠剩余期间的变化。血清甲状腺球蛋白（Tg）水平与甲状腺功能测试（TFTs）和 SAT 的病程相关性最好。
在妊娠期间诊断 SAT 可能会让人感到好奇。循环细胞因子的测量无助于疾病的鉴别诊断或监测。
