Eldeirawi Kamal, McConnell Rob, Furner Sylvia, Freels Sally, Stayner Leslie, Hernandez Eva, Amoruso Lisa, Torres Shioban, Persky Victoria
Public Health, Mental Health, and Administrative Nursing, Department of Health Systems Science, College of Nursing, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
J Asthma. 2010 May;47(4):473-7. doi: 10.3109/02770901003759428.
This study examined the associations of history of ear infections in infancy with doctor-diagnosed asthma in a large sample of Mexican American children.
In this population-based cross-sectional study, parents of 2023 children completed a questionnaire that collected data on doctor-diagnosed asthma, doctor-diagnosed ear infections, as well as antibiotics use in infancy, and other potential confounding variables.
Children with a history of ear infections in infancy were more likely to have asthma compared with those who had no history of ear infections in infancy; the adjusted odds ratios (ORs) were 2.52 (95% confidence interval [CI]: 1.35-4.69) and 1.27 (95% CI: 0.79-2.04) in children who had >or=3 and 1-2 (versus none) ear infections in infancy, respectively, p for trend = .0074. These associations were independent of antibiotics use, acetaminophen consumption, and history of various infections (other than ear infections) in the first year of life. In stratified analyses, the increased risk of asthma in children with recurrent ear infections in infancy persisted among children whose parents reported no lifetime history of rhinitis but not in children who had a history of rhinitis.
This study demonstrated significant associations of asthma with history of ear infections in infancy, with a significant dose-response effect of repeated ear infections on the odds of asthma. These findings add to the growing body of literature linking early childhood infections with the risk of asthma and highlight the need for more research to identify the mechanisms through which ear infections may be associated with asthma.
本研究在大量墨西哥裔美国儿童样本中，考察了婴儿期耳部感染史与医生诊断的哮喘之间的关联。
在这项基于人群的横断面研究中，2023名儿童的家长完成了一份问卷，该问卷收集了有关医生诊断的哮喘、医生诊断的耳部感染、婴儿期抗生素使用情况以及其他潜在混杂变量的数据。
与婴儿期无耳部感染史的儿童相比，婴儿期有耳部感染史的儿童患哮喘的可能性更大；在婴儿期有≥3次和1 - 2次（与无耳部感染相比）耳部感染的儿童中，调整后的优势比（OR）分别为2.52（95%置信区间[CI]：1.35 - 4.69）和1.27（95%CI：0.79 - 2.04），趋势检验p值 = 0.0074。这些关联独立于抗生素使用、对乙酰氨基酚摄入以及出生后第一年各种感染（耳部感染除外）的病史。在分层分析中，婴儿期反复耳部感染儿童哮喘风险增加的情况在父母报告无终生鼻炎病史的儿童中持续存在，但在有鼻炎病史的儿童中则不存在。
本研究表明哮喘与婴儿期耳部感染史之间存在显著关联，反复耳部感染对哮喘几率有显著的剂量反应效应。这些发现增加了将儿童早期感染与哮喘风险联系起来的文献数量，并强调需要更多研究来确定耳部感染可能与哮喘相关的机制。
