Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa.
Drug Dev Ind Pharm. 2010 Dec;36(12):1497-510. doi: 10.3109/03639045.2010.488648. Epub 2010 Jun 9.
Hydrophilic matrix formulations are important and simple technologies that are used to manufacture sustained release dosage forms.
Hydroxypropyl methylcellulose-based matrix tablets, with and without additives, were manufactured to investigate the rate of hydration, rate of erosion, and rate and mechanism of drug release. Scanning electron microscopy was used to assess changes in the microstructure of the tablets during drug release testing and whether these changes could be related to the rate of drug release from the formulations.
The results revealed that the rate of hydration and erosion was dependent on the polymer combination(s) used, which in turn affected the rate and mechanism of drug release from these formulations. It was also apparent that changes in the microstructure of matrix tablets could be related to the different rates of drug release that were observed from the test formulations.
The use of scanning electron microscopy provides useful information to further understand drug release mechanisms from matrix tablets.
亲水基质制剂是一种重要且简单的技术，用于制造缓控释剂型。
制备了含有和不含有添加剂的羟丙甲纤维素基质片，以研究水合速度、溶蚀速度以及药物释放的速度和机制。扫描电子显微镜用于评估药物释放试验过程中片剂微观结构的变化，以及这些变化是否与制剂中药物释放的速度有关。
结果表明，水合和侵蚀的速度取决于所使用的聚合物组合，这反过来又影响了这些制剂中药物释放的速度和机制。显然，基质片剂微观结构的变化可能与从测试制剂中观察到的不同药物释放速度有关。
扫描电子显微镜的使用为进一步了解基质片剂中药物释放机制提供了有用的信息。
