Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark.
Acta Psychiatr Scand. 2010 Nov;122(5):356-66. doi: 10.1111/j.1600-0447.2010.01576.x.
The first episode of schizophrenia is a critical period for illness course and outcomes. We aimed to investigate treatments and outcomes during the first year after the diagnosis of schizophrenia.
Pharmacoepidemiologic inception cohort study of all newly diagnosed patients with schizophrenia in Denmark (n = 13,600) 1996-2005.
From 1996 to 2005, the mean age at first diagnosis decreased significantly (29.2-26.1 years), more patients received antipsychotics (67.2-80.7%, annual OR = 1.07, CI: 1.06-1.09, P < 0.001) and antipsychotic polypharmacy for >4 months (16.7-37.1%, OR = 1.14, CI: 1.12-1.57, P < 0.001). The antipsychotic defined daily dosage (DDD) doubled (150-332 DDD, P < 0.001), use of antidepressants (24.3-40.6%, P < 0.001). Bed days [89.9 days (CI: 81.8-98.8) to 71.8 days, CI: 63.7-80.8, P < 0.0001] decreased, whereas outpatient contacts [10.2 (CI: 9.5-11.0) to 21.4 (CI: 19.9-21.0), P < 0.0001] doubled.
Between 1996 and 2005, there was an earlier recognition of schizophrenia, intensified outpatient treatment, increased use and dosing of antipsychotics and antidepressants, but also more antipsychotic polypharmacy.
精神分裂症的首发期是疾病进程和结局的关键时期。我们旨在研究精神分裂症确诊后第一年的治疗方法和结果。
这是一项针对丹麦所有新确诊精神分裂症患者（1996-2005 年共 13600 人）的药物流行病学起始队列研究。
1996 年至 2005 年间，首次诊断的平均年龄显著下降（29.2 岁至 26.1 岁），更多患者接受了抗精神病药物（67.2%至 80.7%，每年 OR = 1.07，CI：1.06-1.09，P < 0.001）和抗精神病药物联合用药（16.7%至 37.1%，OR = 1.14，CI：1.12-1.57，P < 0.001），超过 4 个月。抗精神病药物的定义日剂量（DDD）增加了一倍（150-332 DDD，P < 0.001），抗抑郁药的使用（24.3%至 40.6%，P < 0.001）。住院天数[89.9 天（CI：81.8-98.8）至 71.8 天，CI：63.7-80.8，P < 0.0001]减少，而门诊接触次数[10.2（CI：9.5-11.0）至 21.4（CI：19.9-21.0），P < 0.0001]增加了一倍。
1996 年至 2005 年间，精神分裂症的早期识别率有所提高，门诊治疗更加强化，抗精神病药和抗抑郁药的使用和剂量增加，但抗精神病药物联合用药也更多。
