Belloso Waldo H, Redal María A
Sección Farmacología Clínica, y Departamento de Farmacología y Toxicología, Instituto Universitario, Escuela de Medicina, Hospital Italiano de Buenos Aires, Argentina.
Medicina (B Aires). 2010;70(3):265-74.
Interindividual variability in the response to drugs is primarily explained by genetic factors. The study of polymorphisms associated with abnormal expression or activity of proteins involved in drug metabolism, transport or pharmacological activity constitutes the basis of pharmacogenomics. Although still in early phases of development, pharmacogenetic analysis in different therapeutic areas significantly contributes to the selection of drugs and doses for the individual patient and is already recognized and recommended by scientific societies, regulatory agencies and public health organisms. The ability to maximize drug efficacy and prevent adverse effects through the analysis of host genetics paves the way to the personalized therapy of the future.
个体对药物反应的差异主要由遗传因素解释。对与药物代谢、转运或药理活性相关蛋白质的异常表达或活性有关的多态性研究构成了药物基因组学的基础。尽管仍处于发展的早期阶段，但不同治疗领域的药物遗传学分析对为个体患者选择药物和剂量有显著贡献，并且已得到科学协会、监管机构和公共卫生组织的认可与推荐。通过分析宿主基因来最大化药物疗效并预防不良反应的能力为未来的个性化治疗铺平了道路。
