Institute of Biotechnology, Graiciūno 8, Vilnius, Lithuania.
Bioinformatics. 2010 Aug 1;26(15):1905-6. doi: 10.1093/bioinformatics/btq306. Epub 2010 Jun 6.
Detection of distant homology is a widely used computational approach for studying protein evolution, structure and function. Here, we report a homology search web server based on sequence profile-profile comparison. The user may perform searches in one of several regularly updated profile databases using either a single sequence or a multiple sequence alignment as an input. The same profile databases can also be downloaded for local use. The capabilities of the server are illustrated with the identification of new members of the highly diverse PD-(D/E)XK nuclease superfamily.
远缘同源检测是研究蛋白质进化、结构和功能的一种广泛应用的计算方法。在这里，我们报告了一个基于序列轮廓-轮廓比较的同源搜索网络服务器。用户可以使用单个序列或多个序列比对作为输入，在几个定期更新的轮廓数据库中的任意一个中进行搜索。相同的轮廓数据库也可以下载用于本地使用。该服务器的功能通过鉴定高度多样化的 PD-(D/E)XK 核酸酶超家族的新成员得到了说明。
