Department of Cardiology, University Hospital of Larissa, Larissa, Greece.
Angiology. 2010 Nov;61(8):737-43. doi: 10.1177/0003319710373091. Epub 2010 Jun 7.
We assessed the association between (CA)n repeat polymorphism of angiotensinogen (AGT), 250 base pair (bp) insertion/deletion (I/D) of angiotensin-converting enzyme (ACE), tetranucleotide repeat polymorphism (TCTG)n of renin (REN), (CT)n repeat polymorphism of the natriuretic peptide receptor A (NPRA) genes, and the presence and extent of coronary artery disease (CAD) in Greek patients with a history of myocardial infarction (MI). A total of 158 post-MI patients referred for coronary angiography were compared with 144 controls. The SS genotype of the AGT gene was related with an increased risk for 3-vessel CAD (odds ratio [OR], 1.94; 95% confidence interval [CI], 1.05-3.61; P = .041), whereas the SL genotype was related with a decreased risk (OR, 0.44; 95% CI, 0.22-0.87; P = .019). Moreover, there was a trend for the SL genotype of the REN gene toward increased risk for CAD. There was a significant association between (CA)n polymorphism of the AGT gene and the extent of CAD in Greek patients with a history of MI.
我们评估了血管紧张素原（AGT）的（CA）n 重复多态性、血管紧张素转换酶（ACE）的 250 碱基对（bp）插入/缺失（I/D）、肾素（REN）的四核苷酸重复多态性（TCTG）n、利钠肽受体 A（NPRA）基因的（CT）n 重复多态性与希腊心肌梗死后史患者冠状动脉疾病（CAD）的存在和严重程度之间的关系。将 158 名接受冠状动脉造影检查的心肌梗死后患者与 144 名对照进行比较。AGT 基因的 SS 基因型与 3 支血管 CAD 的风险增加相关（比值比 [OR]，1.94；95%置信区间 [CI]，1.05-3.61；P =.041），而 SL 基因型与风险降低相关（OR，0.44；95%CI，0.22-0.87；P =.019）。此外，REN 基因的 SL 基因型与 CAD 的风险增加有一定的趋势。在有心肌梗死后史的希腊患者中，AGT 基因的（CA）n 多态性与 CAD 的严重程度之间存在显著相关性。
