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先天性血栓形成倾向与癌症患者中心静脉导管相关性血栓形成。

Congenital thrombophilia and central venous catheter-related thrombosis in patients with cancer.

机构信息

Department of internal medicine, University Hospital Maastricht, Netherlands.

出版信息

Clin Appl Thromb Hemost. 2010 Dec;16(6):643-9. doi: 10.1177/1076029610371471. Epub 2010 Jun 7.

Abstract

Central venous catheter (CVC)-related thrombosis is a frequently occurring complication and may cause significant morbidity in patients with cancer. The aim of this review is to discuss the main studies that examined whether a state of thrombophilia increases the risk of CVC-related thrombosis in patients with cancer. The studies were retrieved by an extensive Medline search. Patients with cancer with a CVC and a factor V Leiden mutation have a higher risk of developing CVC-related thrombosis than patients with cancer having a CVC without the mutation. The scarce information available suggests hyperhomocysteinemia to be a risk factor for CVC-related thrombosis. For other congenital thrombophilia factors, the available data are too limited to allow for any definitive conclusions to be made. Because the clinical implications of all these findings remain to be clarified, routine screening of patients with cancer having a CVC for thrombophilia cannot yet be recommended on the basis of the studies discussed.

摘要

中心静脉导管(CVC)相关性血栓形成是一种常见的并发症,可能会给癌症患者带来严重的发病率。本综述的目的是讨论主要的研究,这些研究检查了血栓形成倾向是否会增加癌症患者 CVC 相关性血栓形成的风险。研究通过广泛的 Medline 搜索获得。与没有突变的癌症患者相比,患有 CVC 和因子 V Leiden 突变的癌症患者发生 CVC 相关性血栓形成的风险更高。目前可获得的有限信息表明,高同型半胱氨酸血症是 CVC 相关性血栓形成的危险因素。对于其他先天性血栓形成倾向因素,目前的数据还太有限,无法得出任何明确的结论。由于所有这些发现的临床意义仍有待阐明,因此目前不能根据所讨论的研究推荐对患有 CVC 的癌症患者进行常规血栓形成倾向筛查。

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