Influence Factors Analyses of PICC-Related Bloodstream Infection, PICC-Related Venous Thrombosis, and Infected Puncture Site and Their Influence on Cancer Patients' Death: A Retrospective Cross-Sectional Study.

PURPOSE

This study aimed to analyze the influence factors affecting catheter-related bloodstream infection, catheter-related thrombosis and catheter-related local complication, respectively, and to explore the relationship among them, as well as the influence of catheter-related bloodstream infection, catheter-related thrombosis and catheter-related local complication on cancer patients' death.

METHODS

The clinical data of 605 patients with solid tumors who underwent PICC from March 2019 to January 2020 in a Chinese hospital were retrospectively analyzed. Chi-square test and logistic regression analyses were used to examine the influence factors affecting catheterrelated bloodstream infection, catheter-related thrombosis and catheterrelated local complication, respectively, and their influence on cancer patients' death during the follow-up period.

RESULTS

The results of logistic regression analyses showed that gender, PICC vascular, PICC tip condition, whether anticoagulant therapy and thrombus location were influence factors of catheter-related bloodstream infection (p < 0.05), however, only whether anticoagulant therapy was risk factors of catheter-related thrombosis [odds ratio (OR) = 7.549, 95% confidence interval (CI): 2.9-19.652, p < 0.05]. In addition, surgical history, PICC tip condition and thrombus location were influence factors of catheter-related local complication (p < 0.05). Furthermore, the results showed that after adjusted by all variables, only catheter-related bloodstream infection was risk factor of cancer patients' death (OR = 11.231, 95% CI: 3.23-39.053, p < 0.05). However, catheter-related thrombosis (OR = 0.793, 95% CI: 0.308-2.043, p > 0.05) and catheter-related local complication (OR = 1.815, 95% CI: 0.715-4.609, p > 0.05) were not significantly associated with patients' death.

CONCLUSION

Overall, the influence factors of catheter-related bloodstream infection, catheter-related thrombosis and catheter-related local complication were significantly different. Moreover, catheter-related bloodstream infection was the risk factor of cancer patients' death. However, catheter-related thrombosis and catheter-related local complication were not significantly associated with patients' death.