Department of Neonatology, Emma Children's Hospital AMC, Amsterdam, The Netherlands.
Arch Dis Child Fetal Neonatal Ed. 2010 Sep;95(5):F369-72. doi: 10.1136/adc.2009.169169. Epub 2010 Jun 7.
Central blood flow measurements can provide detailed information on the hemodynamic condition of the preterm infant. However, reference values for right and left ventricular output (RVO and LVO) and superior vena cava flow (SVC flow) are only available for infants in the transitional period. The aim of this study was to determine RVO, LVO and SVC after the transitional period in stable preterm infants.
RVO, LVO and SVC flow were measured with functional echocardiography on days 7 and 14 of life in stable preterm infants less than 32 weeks gestation, with minimal respiratory support and no cardiovascular support. Infants with a clinical suspicion of an infection within 48 h after data collection or a ductal diameter >1.4 mm were excluded from analysis.
We performed 111 measurements in 62 preterm infants with a median (range) gestational age of 28 (25-31) weeks and birth weight of 1105 (650-2370) g. 57 measurements were analysed on day 7 and 47 on day 14. The mean (SD) RVO, LVO and SVC flow were 429 (116), 296 (74) and 89 (33) ml/kg/min on day 7 and 433 (81), 300 (79) and 86 (26) ml/kg/min on day 14. There were no significant differences in flows between days 7 and 14 in the paired measurements.
This study provides central blood flow values in stable preterm infants after the transitional period. The flow variables were shown to remain stable between days 7 and 14.
中心血流测量可以提供有关早产儿血液动力学状况的详细信息。然而，右心室输出量（RVO）和左心室输出量（LVO）以及上腔静脉血流（SVC 血流）的参考值仅适用于过渡期的婴儿。本研究旨在确定稳定早产儿过渡期后 RVO、LVO 和 SVC。
对胎龄小于 32 周、呼吸支持最小且无心血管支持的稳定早产儿，在生后 7 天和 14 天行功能超声心动图测量 RVO、LVO 和 SVC 血流。在数据采集后 48 小时内有临床感染怀疑或导管直径>1.4mm 的婴儿被排除在分析之外。
我们对 62 名胎龄中位数（范围）为 28（25-31）周和出生体重为 1105（650-2370）g 的早产儿进行了 111 次测量。57 次测量在第 7 天进行，47 次测量在第 14 天进行。第 7 天和第 14 天的平均（标准差）RVO、LVO 和 SVC 血流分别为 429（116）、296（74）和 89（33）ml/kg/min 和 433（81）、300（79）和 86（26）ml/kg/min。配对测量中，第 7 天和第 14 天的流量无显著差异。
本研究提供了过渡期后稳定早产儿的中心血流值。流量变量在第 7 天和第 14 天之间保持稳定。
