[替诺昔康的时间治疗法]
[Chronotherapy of tenoxicam].
作者信息
Reinberg A, Manfredi R, Kahn M F, Chaouat D, Chaouat Y, Delcambre B, Le Goff P, Maugars Y, Valat J P
机构信息
Fondation A. de Rothschild, CNRS, URA 581, Paris.
出版信息
Therapie. 1991 Mar-Apr;46(2):101-8.
A study was carried out in order to investigate the chronotherapy (dosing time dependency) of an NSAID, the tenoxicam administered in ankylosing spondylitis, rheumatoid arthritis and osteoarthritis of the hip. These variations in efficacy exist as much for pain as for stiffness and maximum efficacy is obtained with administration at 8 am or 12 pm. Since the tolerance was good, we recommend midday as an optimal once-a-day dosing time.
为研究非甾体抗炎药（NSAID）替诺昔康在强直性脊柱炎、类风湿关节炎和髋骨关节炎中的时辰治疗法（给药时间依赖性）开展了一项研究。在疼痛和僵硬方面均存在疗效差异，上午8点或中午12点给药可获得最大疗效。由于耐受性良好，我们建议将中午作为每日一次给药的最佳时间。
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