Department of Pediatrics, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy.
J Endocrinol Invest. 2011 Jan;34(1):38-44. doi: 10.1007/BF03346693. Epub 2010 Jun 4.
Allopregnanolone, a neuroactive steroid mainly secreted by adrenals and gonads, is a hormone that seems to play a role in precocious puberty, as demonstrated by its high baseline levels found in girls with central precocious puberty (CPP). Allopregnanolone concentrations significantly increase after GnRH and ACTH stimulation test suggesting both its ovarian and adrenal production.
Aim of this study was to evaluate allopregnanolone concentrations after GnRH and GnRH agonist analog stimulation test in girls with CPP to better establish its secretion source.
Gonadotropins and steroid hormones were evaluated in different days after GnRH and triptorelin stimulation test in 15 CPP girls.
After GnRH stimulation, LH, FSH, and allopregnanolone concentrations significantly increased (p<0.05). After triptorelin administration LH, FSH, estradiol and DHEAS levels significantly increased (p<0.05), while allopregnanolone concentrations significantly decreased (1.08±0.24 vs 0.87±0.28 nmol/l; p=0.003).
The different response of allopregnanolone to GnRH and GnRH agonist analog might reflect the agonist and antagonist action exerted by these secretagogues. Our data suggest the prevalent gonadal allopregnanolone production in CPP subjects and the usefulness of its measurement in the diagnosis of CPP.
作为一种主要由肾上腺和性腺分泌的神经活性甾体，别孕烯醇酮似乎在性早熟中发挥作用，这一点可以从中枢性性早熟（CPP）女孩中发现的高基础水平别孕烯醇酮得到证明。在 GnRH 和 ACTH 刺激试验后，别孕烯醇酮浓度显著增加，提示其具有卵巢和肾上腺的产生功能。
本研究旨在评估 CPP 女孩在 GnRH 和 GnRH 激动剂类似物刺激试验后的别孕烯醇酮浓度，以更好地确定其分泌来源。
在 15 名 CPP 女孩中，在不同天数评估 GnRH 和曲普瑞林刺激试验后的促性腺激素和类固醇激素。
在 GnRH 刺激后，LH、FSH 和别孕烯醇酮浓度显著增加（p<0.05）。在曲普瑞林给药后，LH、FSH、雌二醇和 DHEAS 水平显著增加（p<0.05），而别孕烯醇酮浓度显著降低（1.08±0.24 对 0.87±0.28 nmol/l；p=0.003）。
别孕烯醇酮对 GnRH 和 GnRH 激动剂类似物的不同反应可能反映了这些分泌物的激动剂和拮抗剂作用。我们的数据表明，CPP 患者中存在主要的性腺别孕烯醇酮产生，并且其测量在 CPP 的诊断中具有一定的应用价值。
