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迟发性维生素K缺乏作为出血原因:在21世纪仍是一个值得关注的问题!

Delayed vitamin K deficiency as a cause of bleeding: still a concern in the 21st century!

作者信息

Kasatkar Priyanka, Shetty Shrimati, Ghosh Kanjaksha

机构信息

National Institute of Immunohaematology, KEM Hospital, Parel, Mumbai, India.

出版信息

Blood Coagul Fibrinolysis. 2010 Sep;21(6):608-10. doi: 10.1097/MBC.0b013e32833b645c.

Abstract

Delayed haemorrhage due to vitamin K deficiency in early infancy has rarely been the cause of acquired hemostatic disorders. We report here 11 cases of vitamin K deficiency bleeding (VKDB), despite receiving appropriate dosage of injectible vitamin K at birth. Bleeding symptoms ranged from excessive bleed from cuts to intracranial bleed. Tuberculosis, diarrhea with intermittent antibiotic therapy were some of the associated symptoms. Laboratory tests confirmed acquired bleeding diathesis due to vitamin K deficiency, which was corrected after adequate vitamin K supplementation. VKDB is not an uncommon phenomenon and should be considered in the differential diagnosis of a child with bleeding diathesis.

摘要

婴儿早期维生素K缺乏所致的迟发性出血很少成为获得性止血障碍的原因。我们在此报告11例维生素K缺乏性出血(VKDB)病例,尽管这些婴儿在出生时已接受了适当剂量的注射用维生素K。出血症状从割伤后出血过多到颅内出血不等。结核病、伴有间歇性抗生素治疗的腹泻是一些相关症状。实验室检查证实因维生素K缺乏导致获得性出血素质,在补充足够的维生素K后得以纠正。VKDB并非罕见现象,在对有出血素质的儿童进行鉴别诊断时应予以考虑。

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