父母受教育程度作为社会经济地位和儿童癌症风险的指标。
Parental educational attainment as an indicator of socioeconomic status and risk of childhood cancers.
机构信息
Department of Public Health, College of Health and Human Sciences, Oregon State University, Corvallis, OR 97333, USA.
出版信息
Br J Cancer. 2010 Jun 29;103(1):136-42. doi: 10.1038/sj.bjc.6605732. Epub 2010 Jun 8.
BACKGROUND
Little has been reported on socioeconomic (SES) patterns of risk for most forms of childhood cancer.
METHODS
Population-based case-control data from epidemiological studies of childhood cancer conducted in five US states were pooled and associations of maternal, paternal and household educational attainment with childhood cancers were analysed. Odds ratios (ORs) and 95% confidence intervals were estimated using logistic regression, controlling for confounders.
RESULTS
Although there was no association with parental education for the majority of cancers evaluated, there was an indication of a positive association with lower education for Hodgkin's and Burkitt's lymphoma and Wilm's tumour, with the ORs ranging from 1.5 to >3.0 times that of more educated parents. A possible protective effect was seen for lower parental education and astrocytoma and hepatoblastoma, with ORs reduced by 30 to 40%.
CONCLUSIONS
These study results should be viewed as exploratory because of the broad nature of the SES assessment, but they give some indication that childhood cancer studies might benefit from a more thorough assessment of SES.
背景
关于大多数儿童癌症形式的社会经济地位（SES）风险模式，鲜有报道。
方法
汇总了在美国五个州进行的儿童癌症流行病学研究中的基于人群的病例对照数据，并分析了母亲、父亲和家庭受教育程度与儿童癌症之间的关系。使用逻辑回归控制混杂因素，估计了比值比（OR）和 95%置信区间。
结果
尽管对于评估的大多数癌症与父母教育程度无关，但霍奇金淋巴瘤和伯基特淋巴瘤以及威尔姆斯瘤与较低教育程度呈正相关，比值比范围为 1.5 至> 3.0 倍，而受教育程度较高的父母。较低的父母教育程度与星形细胞瘤和肝母细胞瘤可能具有保护作用，比值比降低了 30%至 40%。
结论
由于 SES 评估的广泛性，这些研究结果应被视为探索性的，但它们表明儿童癌症研究可能受益于对 SES 的更全面评估。
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