这是一个扣人心弦的发现：CCN3 抑制新生内膜增厚。
It's a knockout: CCN3 suppresses neointimal thickening.
机构信息
CIHR Group in Skeletal Development and Remodeling, Division of Oral Biology, Department of Dentistry, Schulich School of Medicine and Dentistry, Dental Sciences Building, University of Western Ontario, London, ON Canada N6A 5C1.
出版信息
J Cell Commun Signal. 2010 Jun;4(2):109-10. doi: 10.1007/s12079-010-0086-y. Epub 2010 Feb 24.
Abstract
The role of CCN proteins in vivo is only just becoming understood. A prototypical member of the CCN family, CCN3 suppresses proliferation. In a study in press, Shimoyama and colleagues show that mice lacking CCN3 have a hyperproliferative response to vascular injury. These data, along with other recent observations, suggest that CCN3 may represent a novel therapy for hyperproliferative diseases.
摘要
CCN 蛋白在体内的作用才刚刚被了解。CCN 家族的典型成员 CCN3 抑制增殖。在一篇即将发表的研究中，Shimoyama 及其同事表明，缺乏 CCN3 的小鼠对血管损伤有过度增殖的反应。这些数据以及其他最近的观察结果表明，CCN3 可能代表一种治疗过度增殖性疾病的新疗法。
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