Bleau Anne-Marie, Planque Nathalie, Perbal Bernard
Université Paris 7-D.Diderot, Laboratoire d Oncologie Virale et Moléculaire, 2 place Jussieu, Case 7048, 75251 Paris Cedex France.
Front Biosci. 2005 May 1;10:998-1009. doi: 10.2741/1594.
The CCN genes encode secreted proteins, associated to the extracellular matrix. They are involved in diverse biological processes such as regulation of cell- adhesion, migration, proliferation, differentiation and survival. They play important roles in pregnancy, development, angiogenesis, wound repair and inflammation. Several lines of evidence support a role for CCN genes in fibrotic disorders and tumorigenesis. We will focus our attention in this review on two CCN proteins: CCN1 and CCN3, that appear to exert distinct and opposite effects. Recent data suggest that CCN1 acts as a tumor-promoting factor and a key regulator in cancer progression, while CCN3 exhibits suppressive capabilities. The possible opposite functions of CCN1 and CCN3 in tumorigenesis, and the relevance of the distinct expression profiles of these two genes observed in many cancers are discussed below.
CCN基因编码与细胞外基质相关的分泌蛋白。它们参与多种生物学过程，如细胞黏附、迁移、增殖、分化和存活的调节。它们在妊娠、发育、血管生成、伤口修复和炎症中发挥重要作用。几条证据支持CCN基因在纤维化疾病和肿瘤发生中的作用。在本综述中，我们将关注两种CCN蛋白：CCN1和CCN3，它们似乎发挥着不同且相反的作用。最近的数据表明，CCN1作为一种肿瘤促进因子和癌症进展的关键调节因子，而CCN3则具有抑制能力。下面将讨论CCN1和CCN3在肿瘤发生中可能的相反功能，以及在许多癌症中观察到的这两个基因不同表达谱的相关性。
