通过 RCM 协议全合成 decarestrictine I 和 botryolide B。

Total synthesis of decarestrictine I and botryolide B via RCM protocol.

机构信息

D-211, Discovery Laboratory, Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad 500 607, India.

出版信息

Org Biomol Chem. 2010 Jul 21;8(14):3130-2. doi: 10.1039/c004556j. Epub 2010 Jun 8.

DOI:10.1039/c004556j

PMID:20532338

Abstract

A convergent stereoselective total synthesis of decarestrictine I (1) and botryolide B (1a) invoking a common synthetic strategy is reported. The key steps are: ring-closing metathesis of epoxy dienoic esters obtained through the Yamaguchi esterification of their respective intermediates to furnish the respective Z-macrocycles (2 and 2a) which were further extrapolated to their respective targets.

摘要

报道了一种收敛的立体选择性全合成 decarestrictine I（1）和 botryolide B（1a）的方法，该方法采用了共同的合成策略。关键步骤为：通过 Yamaguchi 酯化反应得到的环氧二烯酸酯进行环 closing 复分解反应，得到各自的 Z-大环（2 和 2a），然后进一步延伸到各自的目标化合物。