Swiss Federal Institute of Technology Zürich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Switzerland.
Angew Chem Int Ed Engl. 2012 Apr 2;51(14):3405-9. doi: 10.1002/anie.201200871. Epub 2012 Feb 29.
A modular and highly stereoselective synthesis of the title compound was developed. Key steps in the assembly of the carbon framework of ripostatin B were a stereoselective Paterson aldol reaction and a high-yielding ring-closing metathesis mediated by Grubbs first generation catalyst. The C15 hydroxy group was established through Tishchenko-Evans reduction in excellent yield and selectivity.
我们开发了一种模块化且高度对映选择性的标题化合物合成方法。在 ripostatin B 的碳骨架组装过程中的关键步骤是立体选择性的 Paterson 羟醛缩合反应和由 Grubbs 第一代催化剂介导的高产率的闭环复分解反应。C15 羟基通过 Tishchenko-Evans 还原以优异的收率和选择性建立。
