[环磷酸腺苷反应元件结合蛋白基因与重度抑郁症的关联]
[Association of cyclic adenosine monophosphate response element-binding protein gene and major depressive disorder].
作者信息
Liu Xiao-hua, Xu Yi-feng, Cui Dong-hong, Jiang San-duo, Qian Yi-ping, Yu Shun-ying, Jiang Kai-da
机构信息
Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, 200030 PR China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010 Jun;27(3):263-6. doi: 10.3760/cma.j.issn.1003-9406.2010.0.006.
OBJECTIVE
To investigate the association between single nucleotide polymorphisms (SNPs) in cyclic adenosine monophosphate response element-binding protein(CREB1) gene and major depressive disorder (MDD).
METHODS
We recruited 105 parent-offspring trios of Chinese descent, extracted whole blood genomic DNA, and genotyped the SNPs in rs10932201 and rs6740584 loci. Single-marker transmission disequilibrium test (TDT), pairwise SNP linkage disequilibrium(LD) and haplotype-based TDT were performed.
RESULTS
No significant association with MDD was observed for SNPs rs10932201 and rs6740584 (P=0.1004 and P=0.4986). However, there was strong positive association between the rs10932201-rs6740584 haplotype and MDD (P=0.00003241), and both haplotypes of A-C and A-T were significantly associated with MDD (P=0.020 and P=0.00022).
CONCLUSION
The rs10932201-rs6740584 haplotype of the CREB1 gene may play an important role in the pathogenesis of MDD.
目的
探讨环磷酸腺苷反应元件结合蛋白1（CREB1）基因单核苷酸多态性（SNP）与重度抑郁症（MDD）之间的关联。
方法
招募105个华裔亲子三联体，提取全血基因组DNA，并对rs10932201和rs6740584位点的SNP进行基因分型。进行单标记传递不平衡检验（TDT）、成对SNP连锁不平衡（LD）和基于单倍型的TDT。
结果
rs10932201和rs6740584 SNP与MDD无显著关联（P = 0.1004和P = 0.4986）。然而，rs10932201-rs6740584单倍型与MDD之间存在强正相关（P = 0.00003241），A-C和A-T单倍型均与MDD显著相关（P = 0.020和P = 0.00022）。
结论
CREB1基因的rs10932201-rs6740584单倍型可能在MDD发病机制中起重要作用。
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