Li Wei, Shan Xiao-yan, Liu Na, Ni Lei, Wang Li-jun, Wang Lin, Cui Shuang, He Xiao-mei, Gong Zhi-yin, Zhao Bo-tao, Zhang Zhi-xin
HLA Laboratory, Beijing Red Cross Blood Center, Beijing, 100088 PR China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010 Jun;27(3):333-4. doi: 10.3760/cma.j.issn.1003-9406.2010.0.021.
To identify a novel HLA-DRB1 allele in Chinese.
A novel HLA-DR allele was detected by PCR-SSP and SBT in a patient with leukemia.
The sequence of the novel allele was different from all other known alleles. The novel allele differed from the closet matching allele HLA-DRB1*1404 by one nucleotide substitution in exon 2, at position 33 T>C, this resulted in an amino acid change from Tyr to His at codon 17.
The novel allele is confirmed as a new HLA allele and it was officially named HLA-DRB1*1461 by WHO Nomenclature Committee in May, 2006.
在中国人群中鉴定一种新的HLA - DRB1等位基因。
采用聚合酶链反应-序列特异性引物（PCR - SSP）和测序分型技术（SBT）在一名白血病患者中检测到一种新的HLA - DR等位基因。
该新等位基因的序列与所有其他已知等位基因均不同。该新等位基因与最相近的匹配等位基因HLA - DRB1*1404在第2外显子的第33位核苷酸处发生了T>C的替换，这导致第17密码子处的氨基酸由酪氨酸变为组氨酸。
该新等位基因被确认为一种新的HLA等位基因，并于2006年5月被世界卫生组织命名委员会正式命名为HLA - DRB1*1461。
