Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan.
World J Gastroenterol. 2010 Jun 14;16(22):2764-70. doi: 10.3748/wjg.v16.i22.2764.
To investigate a relationship between the clinicopathological features and mucin phenotypes in advanced gastric adenocarcinoma (AGA).
Immunohistochemical staining was performed to determine the mucin phenotypes in 38 patients with differentiated adenocarcinomas (DACs), 9 with signet-ring cell carcinomas (SIGs), and 48 with other diffuse-type adenocarcinomas (non-SIGs) of AGA. The mucin phenotypes were classified into 4 types: gastric (G), gastrointestinal (GI), intestinal, and unclassified.
The G-related mucin phenotypes were highly expressed in all the histological subtypes of AGA. The expression of the GI phenotype in SIG patients was lower than that in DAC patients (P = 0.02), and this phenotype was observed in 56% of the non-SIG patients in the intramucosal layer. Among non-SIG cases, the expression of the GI phenotype was significantly higher in patients with extended adenocarcinomas and those with positive rates of lymph node metastasis. There was no difference between the expressions of the G and other GI phenotypes factors. Among DAC and non-SIG patients, there were no differences between the survival rates of the corresponding patient groups.
The GI phenotype might possess more invasive characteristics than the G phenotype in non-SIG. Neither of the phenotypes indicated a poor prognosis of DAC and non-SIG.
探讨晚期胃腺癌（AGA）临床病理特征与黏蛋白表型的关系。
对 38 例分化腺癌（DAC）、9 例印戒细胞癌（SIG）和 48 例其他弥漫型腺癌（非-SIG）患者的黏蛋白表型进行免疫组织化学染色。将黏蛋白表型分为 4 型：胃型（G）、胃肠型（GI）、肠型和未分类型。
G 相关黏蛋白表型在 AGA 的所有组织学亚型中均高度表达。SIG 患者 GI 表型的表达低于 DAC 患者（P=0.02），并且在黏膜层的 56%的非-SIG 患者中观察到这种表型。在非-SIG 病例中，GI 表型在广泛型腺癌和有淋巴结转移阳性率的患者中的表达显著更高。G 和其他 GI 表型因子的表达无差异。在 DAC 和非-SIG 患者中，相应患者组的生存率无差异。
与 G 表型相比，GI 表型在非-SIG 中可能具有更强的侵袭性特征。两种表型均不能预示 DAC 和非-SIG 的不良预后。
