Sato Seijiro, Hosaka Yasuko, Togashi Kenichi
Department of Thoracic Surgery, Japanese Red Cross Nagaoka Hospital, Nagaoka, Japan.
Kyobu Geka. 2010 Jun;63(6):459-61.
We report a patient who was diagnosed with synovial sarcoma based on gene expression analysis. A 39-year-old male visited a local hospital due to left chest pain. Chest compued tomography (CT) showed a lung tumor located mainly at the lingula of the left lung, and extending to the bifurcation of the upper and lower lobar bronchi. Left pneumonectomy was performed. Pathological examination showed a mesenchymal tumor consisting of short-spindle, small, round cells, and the differentiation between synovial sarcoma and peripheral neuroectodermal tumor was necessary. RT-PCR to examine the gene expression of cells revealed a SYT-SSX fusion gene, and a diagnosis of primary synovial sarcoma of the lung was made.
我们报告了一名基于基因表达分析被诊断为滑膜肉瘤的患者。一名39岁男性因左胸痛前往当地医院就诊。胸部计算机断层扫描（CT）显示肺部肿瘤主要位于左肺舌叶，并延伸至上下叶支气管分叉处。进行了左肺切除术。病理检查显示为一种由短梭形、小圆形细胞组成的间叶性肿瘤，需要鉴别滑膜肉瘤和外周神经外胚层肿瘤。检测细胞基因表达的逆转录聚合酶链反应（RT-PCR）显示存在SYT-SSX融合基因，从而诊断为原发性肺滑膜肉瘤。
