Ito Tetsushi, Kim Kyeongil, Taira Masahiro, Kinoshita Masao, Ikeda Norihiko
Department of Thoracic Surgery, Toda Chuo General Hospital, Toda, Japan.
Kyobu Geka. 2010 Jun;63(6):505-7.
We report a rare case of an atypical carcinoid of the lung with the elevation of serum ProGRP. A 79-year-old female was referred to our hospital presenting with an abnormal shadow by a chest X-ray film. Chest computed tomography (CT) scan revealed a well-defined solitary nodule in the left lower lobe. The serum level of ProGRP was elevated to 2.267 pg/ml (normal range: <46 pg/ml). Pulmonary carcinoid was pathologically suggested by a transbronchial lung biopsy. Considering the patient's general condition, a partial wide resection was performed. Pathological diagnosis was atypical carcinoid. After the operation, further increase of the serum ProGRP level was noted, and multiple liver metastases developed.
我们报告一例血清胃泌素释放肽前体(ProGRP)升高的罕见肺非典型类癌病例。一名79岁女性因胸部X线片显示异常阴影而转诊至我院。胸部计算机断层扫描(CT)显示左下叶有一个边界清晰的孤立结节。血清ProGRP水平升高至2.267 pg/ml(正常范围:<46 pg/ml)。经支气管肺活检病理提示为肺类癌。考虑到患者的一般情况,进行了部分广泛切除。病理诊断为非典型类癌。术后,血清ProGRP水平进一步升高,并出现多发肝转移。