巴西亚马逊地区与莱姆病无关的皮肤病患者对伯氏疏螺旋体严格意义上的抗原的抗体反应性。

Antibody reactivity to Borrelia burgdorferi sensu stricto antigens in patients from the Brazilian Amazon region with skin diseases not related to Lyme disease.

机构信息

Dermatology Division, Fundação de Medicina Tropical do Amazonas (FMT-AM), Manaus, Amazonas State, Brazil.

出版信息

Int J Dermatol. 2010 May;49(5):552-6. doi: 10.1111/j.1365-4632.2010.04393.x.

DOI:10.1111/j.1365-4632.2010.04393.x

PMID:20534091

Abstract

In the present study, we report the occurrence of borreliosis in patients from the Brazilian Amazonic region. Nineteen (7.2%) out of 270 dermatological patients with different skin diseases (no one with clinical Lyme disease), tested positive by ELISA for Borrelia burgdorferi. Serum samples from 15 out of the 19 ELISA-positive patients were further evaluated by Western blot. Presence of Borrelia burgdorferi specific IgG was confirmed in eight (53.3%) out of the 15 patients. All eight patients with ELISA and Western blot positive reactions were treated with doxycycline, according to the Centers for Disease Control and Prevention guidelines. One of them had clinical manifestations of colagenosis and was sent to the Department of Internal Medicine for further investigation. Data presented here suggested that borreliosis "lato sensu" is in the Brazilian Amazon region.

摘要

在本研究中，我们报告了在来自巴西亚马逊地区的患者中发生的莱姆病。270 名患有不同皮肤病的皮肤科患者（无一例具有临床莱姆病）中，19 名（7.2%）通过 ELISA 检测出伯氏疏螺旋体阳性。19 名 ELISA 阳性患者中的 15 名进一步通过 Western blot 进行评估。在 15 名患者中，有 8 名（53.3%）确认存在伯氏疏螺旋体特异性 IgG。根据疾病控制和预防中心的指南，对所有 8 名 ELISA 和 Western blot 阳性反应的患者使用多西环素进行治疗。其中一名患者有胶原病的临床表现，并被送往内科进行进一步检查。这里提供的数据表明，在巴西亚马逊地区存在“广义”莱姆病。