Orlando G, Di Cocco P, D'Angelo M, Clemente K, Famulari A, Pisani F
Renal Failure and Transplant Surgery, University of L'Aquila, L'Aquila, Italy.
Transplant Proc. 2010 May;42(4):1011-3. doi: 10.1016/j.transproceed.2010.03.066.
The objective of regenerative medicine (RM) and Tissue Engineering (TE) is to create living functional tissues to repair or replace tissues or organ functions. This field holds the promise of regenerating damaged tissues and organs in the body. It has the potential to solve the problems of organ shortage and of toxicities deriving from life-long immunosuppression. In fact, cells in the regenerated organ would match those of the patient, from whom they would normally be derived. In the past decade, RM/TE has achieved striking results which are of interest to the transplant community. However, major roadblocks on the avenue to full success include the need for a deeper understanding of cell biology and of interactions with the extracellular matrix. We are presently not able to grow and expand cells indefinitely and safely in various scenarios where RM/TE may be indicated. The production of adequately vascularized scaffolds to optimize nutrients and oxygen delivery, assessment of the viability and function of the cells in the bioengineered construct, and the costs remain areas of scientific research.
再生医学（RM）和组织工程（TE）的目标是创建有生命的功能性组织，以修复或替代组织或器官功能。该领域有望在体内再生受损组织和器官。它有可能解决器官短缺以及终身免疫抑制带来的毒性问题。事实上，再生器官中的细胞将与患者的细胞相匹配，这些细胞通常来源于患者自身。在过去十年中，RM/TE取得了令移植界感兴趣的显著成果。然而，通向完全成功的道路上的主要障碍包括需要更深入地了解细胞生物学以及细胞与细胞外基质的相互作用。目前，在各种可能应用RM/TE的情况下，我们还无法无限期且安全地培养和扩增细胞。生产具有充分血管化的支架以优化营养物质和氧气输送、评估生物工程构建体中细胞的活力和功能以及成本问题，仍然是科研领域。
