Once-a-day administration of everolimus, cyclosporine, and steroid after renal transplantation: a review of the rationale.

The Evidence study (EVerolImus once-a-Day rEgimen with Neoral versus Corticosteroid Elimination) sought to compare once-a-day administration with steroid withdrawal versus twice-daily administration among de novo kidney transplant recipients treated with everolimus, cyclosporine, and steroids. This article describes the study design and rationale of once-daily administration and steroid withdrawal among recipients of de novo kidney transplants treated with everolimus and cyclosporine.