Djoussé Luc, Kamineni Aruna, Nelson Tracy L, Carnethon Mercedes, Mozaffarian Dariush, Siscovick David, Mukamal Kenneth J
Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02120, USA.
Am J Clin Nutr. 2010 Aug;92(2):422-7. doi: 10.3945/ajcn.2010.29406. Epub 2010 Jun 9.
Type 2 diabetes (T2D) remains an important public health issue in the United States. There are limited and inconsistent data on the association between egg consumption and fasting glucose or incident diabetes.
We assessed the association between egg intake and incident diabetes in older adults.
In this prospective study of 3898 men and women from the Cardiovascular Health Study (1989-2007), we assessed egg consumption by using a picture-sorted food questionnaire and ascertained incident T2D annually by using information on hypoglycemic agents and plasma glucose. We used Cox proportional hazards models to estimate adjusted relative risks.
During a mean follow-up of 11.3 y, 313 new cases of T2D occurred. Crude incidence rates of T2D were 7.39, 6.83, 7.00, 6.72, and 12.20 per 1000 person-years in people who reported egg consumption of never, <1 egg/mo, 1-3 eggs/mo, 1-4 eggs/wk, and almost daily, respectively. In multivariable-adjusted models, there was no association between egg consumption and increased risk of T2D in either sex and overall. In a secondary analysis, dietary cholesterol was not associated with incident diabetes (P for trend = 0.47). In addition, egg consumption was not associated with clinically meaningful differences in fasting glucose, fasting insulin, or measures of insulin resistance despite small absolute analytic differences that were significant.
In this cohort of older adults with limited egg intake, there was no association between egg consumption or dietary cholesterol and increased risk of incident T2D.
2型糖尿病（T2D）在美国仍然是一个重要的公共卫生问题。关于鸡蛋摄入量与空腹血糖或糖尿病发病之间的关联，数据有限且不一致。
我们评估了老年人鸡蛋摄入量与糖尿病发病之间的关联。
在这项对心血管健康研究（1989 - 2007年）中3898名男性和女性进行的前瞻性研究中，我们使用图片分类食物问卷评估鸡蛋摄入量，并通过使用降糖药物和血糖信息每年确定新发T2D病例。我们使用Cox比例风险模型来估计调整后的相对风险。
在平均11.3年的随访期间，发生了313例新的T2D病例。报告从不食用鸡蛋、每月食用鸡蛋少于1个、每月食用1 - 3个鸡蛋、每周食用1 - 4个鸡蛋以及几乎每天食用鸡蛋的人群中，T2D的粗发病率分别为每1000人年7.39、6.83、7.00、6.72和12.20例。在多变量调整模型中，无论男女总体上，鸡蛋摄入量与T2D风险增加之间均无关联。在一项次要分析中，膳食胆固醇与糖尿病发病无关（趋势P值 = 0.47）。此外，尽管存在虽小但具有统计学意义的绝对分析差异，但鸡蛋摄入量与空腹血糖、空腹胰岛素或胰岛素抵抗指标的临床显著差异无关。
在这个鸡蛋摄入量有限的老年人群队列中，鸡蛋摄入量或膳食胆固醇与T2D发病风险增加之间无关联。
