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小肠细菌过度生长在肠易激综合征和慢性非特异性腹泻患者中的频率。

Frequency of small intestinal bacterial overgrowth in patients with irritable bowel syndrome and chronic non-specific diarrhea.

机构信息

Department of Gastroenterology, Sanjay Gandhi Post Graduate, Institute of Medical Sciences, Lucknow, India.

出版信息

J Neurogastroenterol Motil. 2010 Jan;16(1):40-6. doi: 10.5056/jnm.2010.16.1.40. Epub 2010 Jan 31.

DOI:10.5056/jnm.2010.16.1.40
PMID:20535325
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2879828/
Abstract

INTRODUCTION: Small intestinal bacterial overgrowth (SIBO) occurs in varying frequency in irritable bowel syndrome (IBS). We studied the frequency of SIBO in IBS and chronic non-specific diarrhea (CNSD). METHODS: 129 patients with IBS (Manning's criteria), 73 with CNSD (>/= 4 weeks diarrhea with two of these tests normal [urine D-xylose, fecal fat and duodenal biopsy]) and 51 healthy controls (HC) were evaluated for SIBO using glucose hydrogen breath test (GHBT). Diarrhea-predominant IBS (D-IBS) was grouped into CNSD. Rise in breath hydrogen 12 ppm above basal following 100 g glucose was diagnostic of SIBO. RESULTS: Of 129 patients with IBS, 7 were constipation (C-IBS), and 122 were of indeterminate type (I-IBS). Patients with IBS were younger than HC and CNSD (IBS vs. HC: 36.6 yr +/- 11.4 vs. 44.1 yr +/- 13.6, p = 0.001; IBS vs. CNSD: 36.6 yr +/- 11.4 vs. 42 yr +/- 14.5, p = 0.003). Patients with CNSD were comparable to HC in age (42 yr +/- 14.5 vs. 44.1 yr +/- 13.6, p = ns). Patients with IBS were more often male than HC [108/129 (83.7%) vs. 34/51 (66.7%) p = 0.02]; gender of CNSD and HC was comparable [male 39/73 (53.4%) vs. 34/51 (66.7%) p = ns]. SIBO was commoner in CNSD than HC [16 (21.9%) vs. 1 (2%), p = 0.003], but was comparable in IBS and HC [11 (8.5%) vs. 1 (2%), p = 0.18]. Patients with CNSD more often had SIBO than IBS [16 (21.9%) vs. 11 (8.5%), p = 0.007]. CONCLUSIONS: SIBO was more common in CNSD including D-IBS than other types of IBS and HC.

摘要

介绍：小肠细菌过度生长（SIBO）在肠易激综合征（IBS）中的发生频率各不相同。我们研究了 SIBO 在 IBS 和慢性非特异性腹泻（CNSD）中的发生频率。

方法：129 例 IBS 患者（Manning 标准）、73 例 CNSD 患者（>/=4 周腹泻，其中两项检查正常[尿 D-木糖、粪便脂肪和十二指肠活检]）和 51 例健康对照（HC）接受葡萄糖氢呼气试验（GHBT）检查 SIBO。腹泻为主型 IBS（D-IBS）被归入 CNSD。葡萄糖 100g 后呼气氢 12ppm 升高超过基础值诊断为 SIBO。

结果：129 例 IBS 患者中，7 例为便秘型（C-IBS），122 例为不定型（I-IBS）。IBS 患者比 HC 和 CNSD 患者年轻（IBS 与 HC：36.6yr +/- 11.4 vs. 44.1yr +/- 13.6，p=0.001；IBS 与 CNSD：36.6yr +/- 11.4 vs. 42yr +/- 14.5，p=0.003）。CNSD 患者与 HC 的年龄相当（42yr +/- 14.5 vs. 44.1yr +/- 13.6，p=ns）。IBS 患者中男性多于 HC [108/129（83.7%）比 34/51（66.7%），p=0.02]；CNSD 和 HC 的性别相似[男性 39/73（53.4%）比 34/51（66.7%），p=ns]。CNSD 患者 SIBO 较 HC 更常见[16（21.9%）比 1（2%），p=0.003]，但 IBS 和 HC 间 SIBO 发生率相当[11（8.5%）比 1（2%），p=0.18]。CNSD 患者 SIBO 较 IBS 更常见[16（21.9%）比 11（8.5%），p=0.007]。

结论：CNSD 包括 D-IBS 中 SIBO 较其他类型 IBS 和 HC 更常见。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc41/2879828/fd1a540e2f27/jnm-16-40-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc41/2879828/fd1a540e2f27/jnm-16-40-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc41/2879828/fd1a540e2f27/jnm-16-40-g001.jpg

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Frequency of small intestinal bacterial overgrowth in patients with irritable bowel syndrome and chronic non-specific diarrhea.

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Indian J Gastroenterol. 2008

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