Research Unit, IMC-Investiláser, Sabadell, Barcelona, Spain.
Lasers Med Sci. 2010 Nov;25(6):767-71. doi: 10.1007/s10103-010-0790-0. Epub 2010 Jun 10.
The epidermal growth factor receptor (EGFR) pathway seems to be an important contributor to the antiproliferative response to photodynamic therapy (PDT), in terms of cell death, apoptosis and tumour destruction. We reviewed all preclinical investigations in the scientific literature on the role of the EGFR pathway in PDT. A systematic search of Medline-indexed references up to March 2010 using the recommended strategies for Medline information retrieval and identifying relevant studies from systematic reviews, revealed 16 full articles that were exhaustively analysed. EGFR inhibition/degradation appeared to be a major effect of PDT in all investigations. PDT was found to result in a time-dependent reduction of EGFR expression, inhibition of tyrosine phosphorylation and induction of apoptosis during the regression of tumours. Within the time period of the PDT reaction, normal and malignant cells lose their responsiveness to EGF. The ERK1/2 and EGFR-PI3K-Akt pathways seem to be involved in cellular survival after PDT. Pharmacotherapy and immunotherapy to block EGFR activity combined with PDT seem to be very effective in reducing malignant tumours in vivo. The effect of PDT is associated with inactivation of the EGFR pathway, but biochemical and cellular phenomena are important and scarcely investigated. EGFR inhibitors and PDT act synergistically, and this is highly relevant for clinical use.
表皮生长因子受体 (EGFR) 途径似乎是光动力疗法 (PDT) 抗增殖反应的一个重要贡献者，就细胞死亡、细胞凋亡和肿瘤破坏而言。我们回顾了科学文献中关于 EGFR 途径在 PDT 中的作用的所有临床前研究。使用 Medline 信息检索的推荐策略对 Medline 索引的参考文献进行了系统搜索，并从系统评价中确定了相关研究，共发现了 16 篇完整的文章，并对其进行了详尽分析。在所有研究中，EGFR 抑制/降解似乎是 PDT 的主要作用。PDT 被发现导致 EGFR 表达的时间依赖性降低、酪氨酸磷酸化抑制和肿瘤消退过程中的细胞凋亡诱导。在 PDT 反应的时间范围内，正常和恶性细胞失去对 EGF 的反应性。ERK1/2 和 EGFR-PI3K-Akt 途径似乎参与了 PDT 后细胞的存活。联合使用 EGFR 活性阻断的药物治疗和免疫疗法与 PDT 似乎非常有效地减少体内恶性肿瘤。PDT 的效果与 EGFR 途径的失活有关，但生化和细胞现象很重要，而且研究甚少。EGFR 抑制剂和 PDT 协同作用，这对临床应用非常重要。
